Our research interests lie at the intersection of organic and medicinal chemistry.  Specific projects include development of new strategies for organic synthesis based on cationic cascades or organophosphorus compounds, design and synthesis of metabolic probes for the isoprenoid biosynthetic pathways, and synthesis of biologically active natural products.   Most of our target compounds are of interest as anti-proliferative agents and have potential applications in oncology.  Close collaborations with colleagues in the UI’s Carver College of Medicine and at the National Cancer Institute – Center for Cancer Research ensure that the compounds we make are carefully evaluated for their biological activity.