The Kohen research group study enzymes that are critical in many biological processes such as de novo DNA synthesis, which are antibiotic and chemotherapeutic drugs targets. We employ an interdisciplinary approach to study catalytic mechanisms, using the approaches of physical-chemistry, organic-chemistry, biochemistry, molecular and structural biology, and radiology. Current projects include: (i) Developing experimental methods to investigate the role of protein motions and quantum mechanics in enzyme catalyzed reactions; (ii) Studies of recently discovered enzymes whose mechanism is not known; and (iii) development of clinical applications of enzyme mechanisms, such as new PET imaging probes for cancer.