- B.A., Bowdoin College (1986)
- Ph.D., Harvard University (1992)
- DOE Distinguished Postdoctoral Fellow, Lawrence Berkeley Laboratory (1993-1995)
Applications of nanoscience and nanotechnology in environmental catalysis, remediation, CWA decontamination, drug delivery; EPR and solid state NMR; synthesis and characterization of nanocrystalline zeolites and zeolite structures.
In the Larsen group, we are interested in the synthesis, spectroscopic characterization and application of novel zeolite materials. Zeolites are crystalline, aluminosilicate molecular sieves which are widely used in applications such as separations, ion exchange and catalysis. Zeolites can be synthesized with a wide range of pore sizes and topologies. The zeolite chemical composition, framework topology and pore size can be varied to control selectivity and reactivity. Although the pore dimensions of these materials are in the nanometer-size range, the zeolite crystals prepared through conventional syntheses are typically on the order of micrometers in diameter. We are interested in the new properties and applications of zeolites with crystal sizes of less than 100 nm. Ongoing projects in the group include 1) synthesis, characterization and application of nanocrystalline zeolites, 2) magnetic resonance (EPR and solid state NMR) studies of zeolite materials , 3) DFT calculations to complement experimental studies and 4) development of undergraduate chemistry laboratory experiments related to nanoscience and nanotechnology.
The main focus of our research is on the synthesis, spectroscopic characterization and application of nanocrystalline zeolites, which are zeolites with discrete, uniform crystals with dimensions of less than 100 nm. Nanocrystalline zeolites are promising catalytic materials that have higher external surface areas and reduced diffusion path lengths relative to conventional micrometer-sized zeolites. In addition, nanometer-sized zeolites can be assembled into optically transparent thin films and other porous nanostructures for use as separation membranes, chemical sensors and photochemical hosts. These new nanocrystalline zeolites have potential applications in environmental protection, decontamination, catalysis and drug delivery. The nanocrystalline zeolite materials can also be used as building blocks for hierarchical zeolite structures, which can be tailored for specific applications. Recently, hollow zeolite structures have been prepared in our lab (see SEM images below) and are being investigated for applications in water purification and drug delivery.
Hollow Zeolite Sphere
Hollow Zeolite Tube
Magnetic Resonance Spectroscopy
We are also interested in magnetic resonance spectroscopy of novel zeolite materials. Electron paramagnetic resonance (EPR) spectroscopy is used to investigate the electronic environment of transition metal-exchanged zeolites. Experimental studies are combined with computational methods to enhance the interpretation of the EPR spectra. Amsterdam Density Functional theory (ADF) methods are used to calculate the EPR parameters. Solid state nuclear magnetic resonance (NMR) techniques are used to study reactions of chemical species that form in the zeolite pores during catalytic reactions. Line-narrowing techniques, such as MAS (magic angle spinning) NMR are routinely employed in these studies.
- Photochemical CO2 Reduction on a Molecular Rhenium Catalyst Adsorbed in a Hierarchical Mesoporous ZSM-5, Kevin D. Dubois, Anton Petushkov,Elizabeth Garcia Cardona, Sarah C. Larsen and Gonghu Li, Journal of Physical Chemistry Letters, 2012, 3, pp 486–492
- Surface Selective Solution NMR Studies of Functionalized Zeolite Nanoparticles, Yulia Tataurova, Michael J. Sealy, Russell G. Larsen, Sarah C. Larsen, Journal of Physical Chemistry Letters, 2012, 3, 425–429
- Synthesis of Nanocrystalline Nab Zeolite with Hierarchical Porosity, Anton Petushkov, Giorvanni Merilis, Sarah C. Larsen, Microporous and Mesoporous Materials, 2011, 143, 97-103.
- Preparation of a Versatile Bifunctional Zeolite for Targeted Imaging Applications, Nicholas Ndiege, Renugan Raidoo, Michael K. Schultz, Sarah Larsen, Langmuir, 2011, 27 (6), pp 2904–2909
- Synthesis of Hierarchical Nanocrystalline ZSM-5 with Controlled Particle Size and Mesoporosity, Anton Petushkov, Suhyoung Yoon, Sarah C. Larsen, Microporous and Mesoporous Materials, 2011, 137, 92-100.
- Toxicity of Silica Nanomaterials: Zeolites, Mesoporous Silica, and Amorphous Silica Nanoparticles (Chapter 7), Anton Petushkov, Nicholas Ndiege, Aliasger K. Salem, Sarah C. Larsen, Adv. Mol. Tox., 2010, Volume 4, 223-266.
- Framework Stability of Nanocrystalline NaY in Aqueous Solution at Varying pH. Anton Petushkov, Jasmine Freeman, Sarah C. Larsen, Langmuir, 2010, 26(9), 6695–6701.
- Pulsed Electron Paramagnetic Resonance Techniques for Structure Determination, William M. Ames, Russell G. Larsen, Sarah C. Larsen, in Encyclopedia of Analytical Chemistry, eds R.A. Meyers, John Wiley: Chichester. UK, DOI: 9780470027318. 2011, p/ 1522-1548
- Synthesis, Characterization and Environmental Applications of Nanocrystalline Zeolites, chapter in Handbook of Nanoscience and Nanotechnology, Volume 3: Materials, Editors A. V. Narlikar, Yunyi Fu, Oxford University Press, Vicki Grassian and Sarah Larsen, Oxford University Press,January, 2010.
- Hyperfine and Quadrupolar Interactions in Vanadyl Proteins and Model Complexes. Theory and Experiment Biological Magnetic Resonance, Vol 29. Metals in Biology: Applications of High Resolution EPR to Metalloenzymes, Editors, Graeme R. Hanson and Lawrence J. Berliner, Springer Publishers, Sarah C. Larsen and N. Dennis Chasteen, invited book chapter, 2010.
- Development of Hands-on Nanotechnology Content Materials: Undergraduate Chemistry and Beyond, Sarah C. Larsen, Norbert Pienta, Russell G. Larsen, invited book chapter for ACS symposium series, Volume 1010, Nanotechnology in Undergraduate Education, edited by Kimberly Pacheco, Richard Schwenz and Wayne Jones, American Chemical Society, 2009, p. 87-99.
- Applications of Nanocrystalline Zeolites tow CWA Decontamination, Vicki Grassian and Sarah Larsen, book chapter in Nanoscience and Nanotechnology for Chemical and Biological Defense, edited by R. Nagarajan, Walter Zukas, T. Alan Hatton and Stephen Lee, American Chemical Society, 2009.
- Chromate Adsorption on Bifunctional, Magnetic Zeolite Composites, Karna Barquist, Sarah C. Larsen, Microporous and Mesoporous Materials, 2010, 130, 197-202
- DFT Calculations of EPR Parameters for Copper(II)-Exchanged Zeolites Using Cluster Models, William M. Ames and Sarah C. Larsen, Journal of Physical Chemistry A, 2010, 114 (1), pp 589–594.
- Effect of Crystal Size and Surface Functionalization on the Cytotoxicity of Silicalite-1 Nanoparticles, Anton Petushkov, Janjira Intra, Jessica B. Graham, Sarah C. Larsen, Aliasger K. Salem, Chemical Research in Toxicology, 2009, 22, 1359-1368.
- DFT Calculations of the EPR Parameters for Cu(II) DETA Imidazole Complexes, William M. Ames and Sarah C. Larsen, Physical Chemistry Chemical Physics, 2009, 11, 8266 – 8274 ( DOI: 10.1039/b905750a).
- A Density Functional Theory Investigation of EPR Parameters for Tetragonal Cu(II) Model Complexes with Oxygen Ligands, William M. Ames and Sarah C. Larsen, Journal of Physical Chemistry A, 2009, 113 (16), pp 4305–4312
- Carbon Dioxide Adsorption in Zeolite Y Materials: A Transmission FTIR Spectroscopy and Quantum Chemical Calculations Study, Pragati Galhotra, Juan Navea, Sarah C. Larsen, Vicki H. Grassian, Energy and Environmental Science, 2009, 2, 401 - 409
- Insight into Copper Coordination Environment in the Prion Protein through DFT Calculations of EPR Parameters, William M. Ames and Sarah C. Larsen, Journal of Biological Inorganic Chemistry, 2009, 14, 547-557