Selected Recent Publications - Gregory K. Friestad

• Korapala, C. S.; Qin, J.; Friestad, G. K. "Quinine Synthesis Studies: A Radical-Ionic Annulation via Mn-Mediated Addition to Chiral N-Acylhydrazones" Org. Lett., 2007, 9, 4246-4249.
• Friestad, G. K.; Mathies, A. K. "Effects of alpha-Alkoxy Substitution and Conformational Constraints on 6-exo Radical Cyclizations of Hydrazones via Reversible Thiyl and Stannyl Additions." Tetrahedron 2007, 63, 9373-9381.
• Friestad, G. K.; Jiang, T.; Mathies, A. K. "Enhanced Reactivity in Radical Cyclizations of Hydrazones Using the Silicon-Tethered 1-Bromovinyl Group." Tetrahedron 2007, 63, 3964-3972.
• Friestad, G. K.; Jiang, T.; Mathies, A. K. "Aldehyde-Selective Wacker Oxidation in a Thiyl-Mediated Vinyl Group Transfer Route to Daunosamine." Org. Lett. 2007, 9, 777-780.
• Friestad, G. K.; Mathies, A. K. "Recent Developments in Asymmetric Catalytic Addition to C=N Bonds." Tetrahedron 2007, 63, 2541-2569.
• Friestad, G. K.; Qin, J.; Suh, Y.; Marié, J.-C. "Mn-Mediated Coupling of Alkyl Iodides and Chiral N-Acylhydrazones: Optimization, Scope, and Evidence for a Radical Mechanism."  J. Org. Chem. 2006, 71, 7016-7027.
• Ding, H.; Friestad, G. K. "Strecker Reactions of Chiral N-Acylhydrazones." Heterocycles 2006, 70, 185-199.
• Friestad, G. K.; Korapala, C. S.; Ding, H.  "Dual Activation in Asymmetric Allylsilane Addition to Chiral N-Acylhydrazones: Method Development, Mechanistic Studies, and Elaboration of Homoallylic Amine Adducts." J. Org. Chem. 2006, 71, 281-289.
• Ding, H.; Friestad, G. K.  "Asymmetric Addition of Allylic Nucleophiles to Imino Compounds."  Synthesis 2005, 2815-2829.
• Friestad, G. K.; Draghici, C.; Soukri, M.; Qin, J. "Radical Addition Approach to Asymmetric Amine Synthesis: Design, Implementation, and Comparison of New Chiral N-Acylhydrazones." J. Org. Chem. 2005, 70, 6330-6338.
• Friestad, G. K. "Chiral N-Acylhydrazones: Versatile Imino Acceptors for Asymmetric Amine Synthesis." Eur. J. Org. Chem. 2005, 3157-3172.
• Friestad, G. K.; Fioroni, G. M. "Haloacetal Radical Cyclizations of alpha- and beta-Hydroxyhydrazones." Org. Lett. 2005, 7, 2393-2396.
• Friestad, G. K.; Deveau, A. M.; Marie, J.-C. "Stereoselective Mn-Mediated Coupling of Functionalized Iodides and Hydrazones: A Synthetic Entry to the Tubulysin gamma-Amino Acids" Org. Lett. 2004, 6, 3249-3252.
• Ding, H.; Friestad, G. K. "Allyltrimethoxysilane Addition to N-Acylhydrazones: Two Catalytic Methods Employing CuCl and Fluoride." Synthesis 2004, 2216-2221.
• Ding, H.; Friestad, G. K. "Trifluoroacetyl-Activated Nitrogen-Nitrogen Bond Cleavage of Hydrazines by Samarium (II) Iodide." Org. Lett. 2004, 6, 637-640.
• Friestad, G. K.; Massari, S. E. "A Silicon Tether Approach for Addition of Functionalized Radicals to Chiral alpha-Hydroxyhydrazones: Diastereoselective Additions of Hydroxymethyl and Vinyl Synthons." J. Org. Chem. 2004, 69, 863-875.
• Friestad, G. K.; Shen, Y.; Ruggles, E. L. "Enantioselective Radical Addition to N-Acylhydrazones Mediated by Chiral Lewis Acids." Angew. Chem. Int. Ed. 2003, 42, 5061-5063.
• Friestad, G. K.; Jiang, T.; Fioroni, G. M. "Tandem Thiyl Radical Addition and Cyclization of Chiral Hydrazones Using a Silicon-Tethered Alkyne." Tetrahedron: Asymmetry 2003, 14, 2853-2856.
• Qin, J.; Friestad, G. K. "Stereocontrol in Hydride Addition to Ketone-Derived Chiral N-Acylhydrazones." Tetrahedron 2003, 59, 6393-6402.
• Shen, Y.; Friestad, G. K. "Comparison of Electrophilic Amination Reagents for N-Amination of 2-Oxazolidinones and Application to Synthesis of Chiral Hydrazones." J. Org. Chem. 2002, 67, 6236-6239.
• Friestad, G. K.; Ding, H. "Asymmetric Allylsilane Additions to Enantiopure N-Acylhydrazones with Dual Activation by Fluoride and In(OTf)₃." Angew. Chem. Int. Ed. 2001, 40, 4491-4493.
• Friestad, G. K.; Qin, J. "Intermolecular Alkyl Radical Addition to Chiral N-Acylhydrazones Mediated by Manganese Carbonyl." J. Am. Chem. Soc. 2001, 123, 9922-9923.
• Friestad, G. K. "Addition of Carbon-Centered Radicals to Imines and Related Compounds" Tetrahedron 2001, 57, 5461-5496.
• Friestad, G. K.; Massari, S. E. "Diastereoselective Vinyl Addition to Chiral Hydrazones via Tandem Thiyl Radical Addition and Silicon-Tethered Cyclization." Org. Lett. 2000, 2, 4237-4240.
• Friestad, G. K.; Qin, J. "Highly Stereoselective Intermolecular Radical Addition to Aldehyde Hydrazones from a Chiral 3-Amino-2-oxazolidinone." J. Am. Chem. Soc. 2000, 122, 8329-8330.
• Friestad, G. K. "A Silicon Tether Approach for Diastereocontrol in Radical Addition to Chiral Hydrazones." Org. Lett. 1999, 1, 1499-1501.