Self-assembly is a tremendously useful technique that is found in almost every area of molecular science. Examples of natural systems that self-assemble include single stranded DNA that self-assembles into duplexes, phospholipids that self-assemble into a lipid bilayer, and long chains of amino acids that self-assemble into proteins with a defined three-dimensional shape. We are interested in studying the process of self-assembly from the molecular to the micron size range and to use self-assembling techniques developed in our group to study problems in polymer and material science. We will synthesize molecules and study their supramolecular properties.

The research in our group will focus on three areas: polymers, self-assembled monolayers (SAMs), and mesoscale self-assembly (MESA). Bottlebrush polymers are a new and interesting set of polymers; they have regularly and densely spaced polymeric arms along the backbone. Steric crowding elongates the backbone; in fact, the polymer resembles a rigid rod whereas traditional linear polymers have an ill-defined globular shape. We will synthesize these polymers and study their self-assembly in solution and in the solid phase.

Self-assembled monolayers of alkanethiols on gold are an excellent model system to study and control surface chemistry. Since their discovery in the 1980’s SAMs have been used as a substrate to grow cells, study protein adsorption, pattern the flow of fluids, provide etch resistance, act as sensors for small molecules, and attach DNA libraries. Alkanethiols form polycrystalline monolayers on the surface of gold, both the process and the result of the self-assembly have been studied. We will synthesize a new set of thiols that will assemble into an unordered monolayer and exhibit lateral diffusion. These surfaces will be responsive, self-healing, and models for cell membranes.

MESA is a new area of self-assembly where objects, not molecules, are self-assembled. We will study the self-assembly of nanometer- and micrometer-sized objects by controlling their surface chemistry to direct their assembly.

The research in our group will be interdisciplinary and cooperative both inside and outside of the group. The borders between traditional areas of chemistry are increasingly being eroded and scientists that can work in this environment are needed. Students trained in this group will receive a strong foundation in traditional synthetic techniques and analysis (NMR, IR, and mass spectroscopy), microscopy (electron, confocal, and fluorescent), and surface chemistry.